Artist interpretation: Cytotoxic T cells (blue) attack a cancer cell (orange). The immune system hosts an army of white blood cells dedicated to helping the body fight infections. One faction of this army includes T cells, a type of white blood cell that develops from stem cells in bone marrow. There are three main types of T cells that each play a different role in the highly-coordinated defense of the body against illness: Regulatory T cells modulate the immune response and prevent other immune cells from becoming overactive. Helper T cells help activate other immune cells once they detect evidence of a foreign invader, such as a virus or cancer. Killer, or cytotoxic, T cells directly attack and destroy cells they recognize as being foreign. Over the past few decades, advancements in immunotherapy have come a long way, and it is now an important part of treating some [...]
When pets are diagnosed with cancer, pet owners can sometimes feel lost about where to find help and information about their options. The best place to start is the family veterinarian. He or she can answer questions and help families navigate a difficult diagnosis. The family vet can help make referrals to veterinary oncologists, and even provide information about the treatment options available for their pet. Learn About Canine Cancer ELIAS Animal Health is committed to developing better treatment options for animal cancer for pets and their families. To support veterinarians and their clients in the quest for information, we've put together some content that speaks plainly and clearly to dog owners and their care teams. We hope these articles and podcasts serve as a resource for you and your clients. The Connection Between Canine and Human Cancer touches on the cross-collaboration between human and canine cancer researchers and how [...]
ELIAS Animal Health Research Demonstrates Cancer-Killing Capabilities of Its Activated T Cell Immunotherapy
In vitro study of the ELIAS Cancer Immunotherapy (ECI®) showed personalized T cell immunotherapy initiated a significant immune response against target cancer cells. OLATHE, Kan., August 10, 2022 -- ELIAS Animal Health recently presented new mechanism of action data for the ELIAS Cancer Immunotherapy (ECI®) at the 2022 American College of Veterinary Internal Medicine Forum. ECI is an adoptive cell therapy that stimulates a patient’s immune system to recognize and attack cancers. ECI uses a personalized vaccine made from a patient’s own cancer cells to “prime” the immune cells to recognize the cancer. These primed immune cells—which are collected from the patient through a procedure called apheresis—are activated and expanded ex vivo for reinfusion into the patient, where they travel to the cancer cells and attack them. In vitro study demonstrates how vaccine-primed T cells mount an immune response against cancer cells [...]
ELIAS Animal Health CEO, Tammie Wahaus, was a recent guest on the Dog Cancer Answers podcast to discuss how the ELIAS Cancer Immunotherapy (ECI) works, the role of a healthy immune system in successful immunotherapy, and why we chose to focus on canine osteosarcoma first. Listen to the episode below, or read the full transcript at Dog Cancer Answers online. Listen to more episodes of the Dog Cancer Answers podcast here.
ELIAS Animal Health CEO, Tammie Wahaus, was the featured guest on the Fuzzybutts & Friends podcast. Hosted by Luke Robinson, founder of the PuppyUp Foundation, the podcast explores how the ELIAS Cancer Immunotherapy (ECI®) works against bone cancer in dogs, as well as how ELIAS is committed to developing more immunotherapies for pets with cancer. Check out the episode below! Learn more about the PuppyUp Foundation here. Watch more episodes of the Fuzzybutts & Friends podcast here.
Immunotherapy is increasingly becoming an important tool in the oncologist’s arsenal to improve clinical outcomes for both human and veterinary patients alike. Studies have shown that immunotherapies can produce durable responses in some patients, both human and companion animals. The power of combining immuno-oncology approaches such as adoptive cell therapies, oncolytic viruses, and checkpoint inhibitors, among others, has the potential to significantly increase the number of patients that become long term survivors. The article, "The future of canine cancer treatment" discusses the research ELIAS Animal Health is doing to evaluate how to improve patient response rates with these combination approaches. Read the full article at Veterinary Practice News online.
It Takes a Village: Understanding the Critical Roles Played by the Care Team Treating Canine Cancer Patients
This is the second part of a series that highlights the innovation, people, and opportunities that have been part of my ELIAS journey. Last week, I focused on solving a problem: treating dogs with cancer using methods that lengthened and improved their quality of life. This segment is dedicated to the people who are part of the solution. The family veterinarian plays an important role in a pet’s life and in the lives of the family who loves them, similar to that of a primary care doctor in the human realm. Through regular check-ups, the family veterinarian keeps the dog healthy. When he or she suspects something is wrong, they assess the issue and connect the pet and owners to a specialist if necessary. When a dog is diagnosed with cancer, it starts a process of care. The initial point of contact is often the family veterinarian, who diagnoses the [...]
Entrepreneurs look to solve problems. Needs spark ideas, ideas spark innovation, and innovation births new companies. We founded ELIAS Animal Health to transform cancer treatment for pets by bring the state-of-the-art therapeutics benefiting humans into the animal world. Chemotherapy has been the standard of care treatment for dogs with cancer for decades. Until recently, it was often the only option available. Chemo kills cancer cells but because it’s so powerful, it damages surrounding healthy cells and ravages the body. Our goal was to find an alternative way to treat canine cancer, one that is effective and less taxing on our canine counterparts. Millions and millions of dollars fund human cancer research and treatment, but our pets traditionally haven’t benefited from it the same way that people have. At ELIAS, we collaborate with our peers in human health to apply the advancements in immunotherapy to animals. Our goal is to bring [...]
In this final installment of the Canine Cancer Continuum, we talk about immunotherapy - what it is, how it works, and how it can help in the fight against cancer. (Check out Part 1 and Part 2.) “Without an immune system, we would have no way to fight harmful things that enter our body from the outside or harmful changes that occur inside our body. The main tasks of the body’s immune system are: to fight disease-causing germs (pathogens) like bacteria, viruses, parasites or fungi, and to remove them from the body, to recognize and neutralize harmful substances from the environment, and to fight disease-causing changes in the body, such as cancer cells.” (National Institutes of Health) In a nutshell, our immune systems are powerful mechanisms designed to protect us and keep us healthy. They work 24/7 to fight off external threats, like viruses and environmental stressors, and internal threats, like stresses to normal [...]
We’re halfway through a series exploring canine cancer. Last week, we discussed the prevalence of dog cancer, and today we will explore the connection between it and human cancer. Human cancer research is extensive. Almost anyone I encounter has either battled cancer themselves or has journeyed that path with someone close to them. Many people are surprised to learn that one in four dogs are diagnosed with cancer and that it’s the leading cause of death in canines. ELIAS Animal Health applies the advancements in human immunotherapy to dogs. They’re good models. From a scientific perspective, we are able to gather data more quickly than in human research because dogs have a shorter lifespan and cancer progresses more quickly in them. From a “we love our furry friends” perspective, we want to bring needed therapies into the veterinary marketplace that help people. ELIAS Cancer Therapies Are Being Simultaneously Developed for Humans [...]