Our Pipeline

At ELIAS Animal Health, our mission is to improve cancer treatment outcomes in veterinary patients through the advancement of innovative therapies. Learn more about our pipeline of innovation and ongoing research below.

I N N O V A T I O N

Product Pipeline

ELIAS Cancer Immunotherapy (ECI®)

The ELIAS Cancer Immunotherapy (ECI®) is the first ever approved product for the treatment of canine osteosarcoma. ECI® has been evaluated in multiple clinical studies and has been used to treat cancer in more than 300 canine patients, both in clinical studies and commercially.

ECI® is a vaccine-enhanced adoptive cell therapy that trains the immune system to target a patient’s unique cancer cells. This personalized approach can improve clinical outcomes and provide a better quality of life for canine patients. As a USDA-approved Autologous Prescription Product, ECI® can also be used by licensed veterinarians to treat other cancers.

ELI352 – Oncolytic Virotherapy

ELIAS Animal Health is developing an oncolytic virotherapy to treat a variety of tumoral cancers in companion animals. ELI352 is a vaccinia viral strain that selectively replicates in cancer cells, causing cell death (apoptosis).1 Though oncolytic viruses only target cancer cells and not healthy cells, they are not selective about which cancer types they attack, making them potentially useful against a variety of cancer types. ELIAS plans to evaluate ELI352 in various indications, including osteosarcoma, oral melanoma, lymphoma, and mast cell tumors.

ELIAS licensed the technology from Genelux Corporation, a clinical stage immuno-oncology company focused on advancing treatments for a broad range of cancer indications in humans. Genelux previously conducted a Phase 1 study in which this oncolytic virus was used to treat dogs diagnosed with several types of cancer.

I N S I G H T S

Clinical Studies & Current Research

Canine Osteosarcoma:
ECI® combined with chemotherapy

Safety and efficacy study of ECI® combined with chemotherapy in dogs newly diagnosed with appendicular osteosarcoma.

Preliminary interim analysis of data from this study (presented at the 2025 ACVIM Forum) showed 71% of dogs receiving ECI® and one dose of carboplatin were alive at one year.

Canine Osteosarcoma:
ECI® combined with novel adjuvant and limb-spare surgery

Safety and efficacy study of ELIAS’s vaccine-enhanced adoptive cell therapy combined with a novel adjuvant as a limb-sparing treatment for large-breed dogs newly diagnosed with appendicular osteosarcoma.

Canine Osteosarcoma:
ECI® combined with gilvetmab

Safety and efficacy study of ELIAS’s vaccine-enhanced adoptive cell therapy combined with gilvetmab, a checkpoint inhibitor, as a treatment for metastatic appendicular osteosarcoma in dogs.

REFERENCES

1. Oncolytic vaccinia virus and cancer immunotherapy. Front. Immunol., 11 January 2024. Sec. Cancer Immunity and Immunotherapy. Volume 14 – 2023 | https://doi.org/10.3389/fimmu.2023.13247