Canine Osteosarcoma Limb-Sparing Clinical Trial (ECIP-OSA-01)

Now enrolling. Contact the participating hospital listed below to see if your patient or dog is eligible.

Trial Overview

ELIAS Animal Health is currently conducting a study to assess safety and efficacy of ELIAS’s vaccine-enhanced adoptive T cell therapy combined with a novel adjuvant as a limb-sparing treatment for large-breed dogs newly diagnosed with appendicular osteosarcoma. The study, which will be funded by a grant from Morris Animal Foundation, will be conducted in collaboration with Dr. Jeffrey Bryan and Dr. Megan Mickelson at the University of Missouri-Columbia.

Trial Summary

  • Treatment includes limb-sparing surgery to remove primary tumor, followed by vaccine-enhanced adoptive T cell therapy combined with a novel adjuvant.
  • Patients must complete the 7-11 week protocol, conducted at the University of Missouri Veterinary School of Medicine, and return for periodic follow-up visits.
  • Each patient will be monitored for 12 months post-diagnosis.

Key Inclusion Criteria

  • Dog breeds eligible for this study include: Anatolian Shepherd, Bernese Mountain Dog, Boerboel, Cane Corso, Dogue de Bordeaux, Golden Retriever, Great Dane, Great Pyrenees, Greater Swiss Mountain Dog, Irish Wolfhound, Leonberger, Mastiff (all types), Newfoundland, Rottweiler, Saint Bernard, and Scottish Deerhound.
  • Eligible patients must be newly diagnosed with appendicular osteosarcoma and must not have received prior treatment for the cancer.
  • Tumor must be in the distal radius or mid-ulnar location; no more than 1/3 radius may be affected.
  • Eligible patients must not have metastatic disease at the time of diagnosis.
  • Pet owner/caregiver must be able and willing to attend all treatment and follow-up visits at the Veterinary Health Center at the University of Missouri in Columbia, MO.

*Additional inclusion/exclusion criteria may apply.

Participating Hospital: Veterinary Health Center at the University of Missouri-Columbia

To see if your dog or canine patient may be a good candidate for treatment, please click the button below to participate in an online screening survey operated by the Veterinary Health Center at the University of Missouri-Columbia.